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Treatment with NR improves cognition in transgenic mice with AD by reducing the phosphorylation of the Tau protein (pTau) (a form that accumulates in the brain of AD patients and is the hallmark of the disease) (Green et al., 2008

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The Office of Dietary Supplements states that none has been established because B12 is regarded as safe even at high doses, with the kidneys clearing the surplus into the urine

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